Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke

Ischemic stroke (IS) occurs as a result of local disturbance hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved regulation tissue oxygen levels, plays an important role pathophysiology stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, blood-brain barrier permeability, IS outcomes. The purpose study was to determine relationship between blood levels HIF-1α degree neurological deficit acute period outcome disease. We examined 58 people with aged 73 (67-81) years. Patients were divided into two groups – discharged dead. severity (NIHSS), deficit, comorbidity index, HIF-1α, p53 protein, interleukin-6, cystatin C, CRP, creatinine, hematological parameters determined at admission, on days 3 10 At admission lower than comparison group remained reduced until 10th day. On day association index disease determined. observed feedback content erythrocytes, hemoglobin hematocrit, can be regarded reflection hemic component mixed hypoxia. In dead patients, increased level C detected, associated concentrations. all periods observation IS, correlation creatinine CRP noted. These results may indicate dysfunction endotheliocytes, inflammation IS. prognostic significance for AUC = 0.900. Blood